@article{Monkcom_Ghosh_Folkertsma_Negenman_Lutz_Klein Gebbink_2020, title={Bioinspired Non-Heme Iron Complexes: The Evolution of Facial N, N, O Ligand Design}, volume={74}, url={https://www.chimia.ch/chimia/article/view/2020_450}, DOI={10.2533/chimia.2020.450}, abstractNote={ Iron-containing metalloenzymes that contain the 2-His-1-Carboxylate facial triad at their active site are well known for their ability to activate molecular oxygen and catalyse a broad range of oxidative transformations. Many of these reactions are synthetically challenging, and developing small molecular iron-based catalysts that can achieve similar reactivity and selectivity remains a long-standing goal in homogeneous catalysis. This review focuses on the development of bioinspired facial N,N,O ligands that model the 2-His-1-Carboxylate facial triad to a greater degree of structural accuracy than many of the polydentate N-donor ligands commonly used in this field. By developing robust, well-defined N,N,O facial ligands, an increased understanding could be gained of the factors governing enzymatic reactivity and selectivity. }, number={6}, journal={CHIMIA}, author={Monkcom, Emily C. and Ghosh, Pradip and Folkertsma, Emma and Negenman, Hidde A. and Lutz, Martin and Klein Gebbink, Robertus J. M.}, year={2020}, month={Jun.}, pages={450} }