@article{Grosheva_Cramer_2019, title={Exploitation of Unconventional Electrophiles in Enantioselective Pd(0)-Catalyzed C–H Functionalizations}, volume={73}, url={https://www.chimia.ch/chimia/article/view/2019_262}, DOI={10.2533/chimia.2019.262}, abstractNote={ Asymmetric metal-catalyzed C–H functionalization is a powerful strategy for the rapid generation of complex target molecules from simple precursors. While aryl (pseudo)halides have been used as electrophilic substrates in enantioselective Pd(0)-catalyzed syntheses of N-heterocycles, alternative partners for C–H functionalizations remain underexplored. Herein we describe the first application of ketene aminal phosphates as competent electrophiles in a Pd(0)-catalyzed desymmetrization. This transformation allowed the efficient synthesis of chiral isoindolines in a highly enantioselective fashion. Furthermore, intending to introduce sought-after perfluoroalkyl substituents, we explored intramolecular C–H functionalization of imidoyl chlorides resulting in the asymmetric preparation of previously inaccessible 1H-isoindoles. Tailored chiral monodentate ligands afforded high levels of enantioinduction in both transformations. }, number={4}, journal={CHIMIA}, author={Grosheva, Daria and Cramer, Nicolai}, year={2019}, month={Apr.}, pages={262} }