TY - JOUR AU - Blondel, Delphine AU - Lutolf, Matthias P. PY - 2019/02/27 Y2 - 2024/03/29 TI - Bioinspired Hydrogels for 3D Organoid Culture JF - CHIMIA JA - Chimia VL - 73 IS - 1-2 SE - Scientific Articles DO - 10.2533/chimia.2019.81 UR - https://www.chimia.ch/chimia/article/view/2019_081 SP - 81 AB - <p>Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.</p> ER -