TY - JOUR AU - Dumas, Anaëlle AU - Peramo, Arnaud AU - Desmaële, Didier AU - Couvreur, Patrick PY - 2016/04/27 Y2 - 2024/03/29 TI - PLGA-PEG-supported Pd Nanoparticles as Efficient Catalysts for Suzuki-Miyaura Coupling Reactions in Water JF - CHIMIA JA - Chimia VL - 70 IS - 4 SE - Scientific Articles DO - 10.2533/chimia.2016.252 UR - https://www.chimia.ch/chimia/article/view/2016_252 SP - 252 AB - Chemical transformations that can be performed selectively under physiological conditions are highly desirable tools to track biomolecules and manipulate complex biological processes. Here, we report a new nanocatalyst consisting of small palladium nanoparticles stabilized on the surface of PLGA-PEG nanoparticles that show excellent catalytic activity for the modification of biological building blocks through Suzuki-Miyaura cross-coupling reactions in water. Brominated or iodinated amino acids were coupled with aryl boronic acids in phosphate buffer in good yields. Interestingly, up to 98% conversion into the coupled amino acid could be achieved in 2 h at 37 °C using the stable, water-soluble cyclic triolborate as organometallic partner in the presence of only 1 mol% of palladium. These results pave the way for the modification of biomolecules in complex biological systems such as the intracellular space. ER -