TY - JOUR AU - Zerbe, Oliver AU - Baumann, Christian AU - Schuster, Matthias AU - Moehle, Kerstin AU - Oi, Kathryn K. AU - Michel, Erich PY - 2021/06/30 Y2 - 2024/03/29 TI - Peptides in BioNMR Research JF - CHIMIA JA - Chimia VL - 75 IS - 6 SE - Scientific Articles DO - 10.2533/chimia.2021.505 UR - https://www.chimia.ch/chimia/article/view/2021_505 SP - 505 AB - Heteronuclear NMR in combination with isotope labelling is used to study folding of polypeptides induced by metals in the case of metallothioneins, binding of the peptidic allosteric modulator ?-TIA to the human G-protein coupled ?1b adrenergic receptor, the development of therapeutic drugs that interfere with the biosynthesis of the outer membrane of Gram-negative bacteria, and a system in which protein assembly is induced upon peptide addition. NMR in these cases is used to derive precise structural data and to study the dynamics. ER -