TY - JOUR AU - Batur, Gokhan AU - Ermert, Philipp AU - Zimmermann, Johann AU - Obrecht, Daniel PY - 2021/06/30 Y2 - 2024/03/29 TI - Macrocycle Therapeutics to Treat Life-threatening Diseases JF - CHIMIA JA - Chimia VL - 75 IS - 6 SE - Scientific Articles DO - 10.2533/chimia.2021.508 UR - https://www.chimia.ch/chimia/article/view/2021_508 SP - 508 AB - Polyphor's macrocycle platform led to the discovery of novel antibiotics addressing specifically Gramnegative bacteria by targeting outer membrane proteins. Furthermore, POL6014, an inhibitor of neutrophile elastase and balixafortide, a CXCR4 inhibitor have been discovered and developed from the platform. Currently a combination of balixafortide and eribulin is in Phase III clinical trial for the treatment of patients with advanced metastatic HER2-negative breast cancer. ER -