TY - JOUR AU - Vorherr, Thomas E. PY - 2021/06/30 Y2 - 2024/03/28 TI - Important Considerations Related to Permeability of Peptides JF - CHIMIA JA - Chimia VL - 75 IS - 6 SE - Scientific Articles DO - 10.2533/chimia.2021.522 UR - https://www.chimia.ch/chimia/article/view/2021_522 SP - 522 AB - This review on intracellular delivery and oral bioavailability of peptides reflects a number of principal investigations at Novartis. Our studies were aimed at either understanding features enabling peptides to interfere with intracellular protein–protein interactions, or to achieve a more patient-friendly delivery by the oral route. In the light of these objectives, we have also spent some effort on assay development to come up with alternative methods for monitoring cellular peptide uptake. This summary of our insights is intended to help in the assessment and development of peptide therapeutics requiring membrane transition ER -