TY - JOUR AU - Zard, Samir Z. PY - 2020/02/26 Y2 - 2024/03/29 TI - The Xanthate Route to Amino Acids JF - CHIMIA JA - Chimia VL - 74 IS - 1-2 SE - Scientific Articles DO - 10.2533/chimia.2020.9 UR - https://www.chimia.ch/chimia/article/view/2020_009 SP - 9 AB - The degenerative xanthate addition transfer to alkenes allows the synthesis of a broad range of protected, and in some cases enantiopure, ?, ?, and ?-amino acids, including proline and pipecolic derivatives, as well as fluorinated congeners and ?-lactams. The radical addition furnishes naturally latent mercapto-?-amino acids that are ideally equipped for native chemical ligation. Most of the amino acid structures accessible rapidly by this chemistry would otherwise require tedious multi-step syntheses. ER -