Proteomics: From Protein Identification to Biological function


  • Jan van Oostrum Novartis Pharma AG, Functional Genomics Area, WSJ-88.10.01, CH-4002 Basel
  • Sjouke Hoving
  • Dieter Müller
  • Patrick Schindler
  • Michel Steinmetz
  • Harry Towbin
  • Hans Voshol
  • Urs Wirth



Mass spectrometry, Protein interactions, Proteomics, Two-dimensional gel electrophoresis


The term 'proteome' describes the expressed protein complement of a genome. The largely invariant genome of an individual or organism determines its potential for gene- and protein expression but does not specify which proteins are expressed in the various types of cells in an organism or individual or their level or extent of post-translational modification. Furthermore, the proteomes of cells are directly affected by environmental factors, such as stress or drug treatment, or by aging and disease. This review briefly describes a selection of the main technologies applied by proteome sciences and their applications to study complex biological problems.




How to Cite

J. van Oostrum, S. Hoving, D. Müller, P. Schindler, M. Steinmetz, H. Towbin, H. Voshol, U. Wirth, Chimia 2001, 55, 354, DOI: 10.2533/chimia.2001.354.