Simulated Moving Bed Chromatography – The Next Step in HPLC



  • Thomas van Oordt
  • Edwin Bayliss
  • Thomas Netscher
  • Werner Bonrath
  • Thomas Spielmann



Preparative chromatography, Simulated moving bed, Tocopherols, Tocotrienols, Vitamin e


Simulated Moving Bed (SMB) technology, a continuous chromatographic separation process, is of increasing interest in the field of pharmaceuticals, fine chemicals, and biotechnology. The complexity of SMB asks for a deeper understanding of the mathematical design and physical adsorption processes, along with the practical training in chromatography and process engineering. This makes SMB a technology which is also suitable for educational purposes. The principle of SMB separation is described with a short introduction of its mathematical design for a simulation. A method of measuring the adsorption isotherms, which are crucial for a process simulation, is also discussed. As an example, the application of SMB to the separation of two groups of biologically important vitamin E compounds, i.e. tocopherols and tocotrienols from natural-source material is presented.




How to Cite

T. van Oordt, E. Bayliss, T. Netscher, W. Bonrath, T. Spielmann, Chimia 2006, 60, 150, DOI: 10.2533/000942906777674967.