From Azidoproline to Functionalizable Collagen


  • Christiane Siebler
  • Roman S. Erdmann
  • Helma Wennemers Laboratorium für Organische Chemie, D-CHAB, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland



Cd spectroscopy, Click chemistry, Collagen, Peptides, Proline


The article summarizes our research devoted to the development of functionalizable collagen using azidoproline-containing model peptides. 'Click chemistry' or Staudinger reduction followed by acylation provided facile access to a range of differently functionalized collagen model peptides bearing e.g. carbohydrates. The research provided not only insight into the factors that are responsible for the high conformational stability of collagen but also a guide in which positions functional moieties are tolerated without or by deliberately disturbing the supramolecular assembly of collagen. The presented research will be useful for the development of collagen-based materials.




How to Cite

C. Siebler, R. S. Erdmann, H. Wennemers, Chimia 2013, 67, 891, DOI: 10.2533/chimia.2013.891.