Non-destructive Localization and Identification of Active Pharmaceutical Compounds by Raman Chemical Imaging



  • Pierre Brodard Ecole d'ingénieurs et d'architectes de Fribourg (EIA-FR), Institut des Technologies Chimiques (ChemTech), Boulevard de Pérolles 80, CH-1705 Fribourg, Switzerland
  • Samuel Roth
  • Olivier Vorlet



Active pharmaceutical ingredients (api), Chemical imaging, Polymer microparticles, Raman spectroscopy


Raman spectroscopy is a powerful and non-destructive technique for chemical and structural identification. Based on inelastic scattering of laser light by molecular vibrations, the analysis can be localized on a microscopic area when combined with a microscope. Thus, by moving the sample under the microscope objective and recording a Raman spectrum at each point, a map of the intensity of specific Raman bands can be generated, effectively creating a chemical image of the sample at the microscale. Here, we present an application of this technique for identifying and localizing active pharmaceutical ingredients in a polymer matrix.




How to Cite

P. Brodard, S. Roth, O. Vorlet, Chimia 2013, 67, 923, DOI: 10.2533/chimia.2013.923.