Non-destructive Localization and Identification of Active Pharmaceutical Compounds by Raman Chemical Imaging
Keywords:Active pharmaceutical ingredients (api), Chemical imaging, Polymer microparticles, Raman spectroscopy
AbstractRaman spectroscopy is a powerful and non-destructive technique for chemical and structural identification. Based on inelastic scattering of laser light by molecular vibrations, the analysis can be localized on a microscopic area when combined with a microscope. Thus, by moving the sample under the microscope objective and recording a Raman spectrum at each point, a map of the intensity of specific Raman bands can be generated, effectively creating a chemical image of the sample at the microscale. Here, we present an application of this technique for identifying and localizing active pharmaceutical ingredients in a polymer matrix.
How to Cite
P. Brodard, S. Roth, O. Vorlet, Chimia 2013, 67, 923, DOI: 10.2533/chimia.2013.923.
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