Challenges and Opportunities in DNA-based Asymmetric Catalysis


  • Michael Smietana Institut des Biomolécules Max Mousseron (IBMM), CNRS Université de Montpellier, ENSCM Place E. Bataillon, CC 1704 34000 Montpellier, France;, Email:
  • Stellios Arseniyadis Queen Mary University of London School of Biological and Chemical Sciences Mile End Road E1 4NS, London, UK;, Email:



Asymmetric catalysis, Bio-hybrid, Chirality, Dna, Double helix


The biological importance of nucleic acids for the storage, expression and regulation of genetic information is now well understood. By taming the chemical synthesis of these biomolecules, chemists have been able to engineer new architectures based on the ability of DNA and RNA to fold into secondary or even more complex tertiary structures with applications in medicinal chemistry, diagnostics or even material sciences. Exploiting the fascinating helical structure of DNA and RNA to develop new chiral bio-hybrid catalysts capable of promoting highly stereoselective transformations under mild and eco-compatible conditions is also an emerging area of research. In this short review, we report our recent results in the field of DNA-based asymmetric catalysis as well as the challenges and promising perspectives that lie in front of us.




How to Cite

M. Smietana, S. Arseniyadis, Chimia 2018, 72, 630, DOI: 10.2533/chimia.2018.630.