Magneto-responsive Cell Culture Substrates that can be Modulated in situ

Authors

  • Federica Crippa
  • Barbara Rothen-Rutishauser
  • Alke Petri-Fink

DOI:

https://doi.org/10.2533/chimia.2019.51

Keywords:

Magnetic nanoparticles, Mechanobiology, Stimuli-responsive substrates

Abstract

Abstract: Understanding the interaction between cells and their environment is fundamental for mechanobiology. To mimic the behavior of cells in physiological and pathological conditions, synthetic substrates must have topographical and/or mechanical properties that evolve in time. Dynamic substrates mainly rely on stimuli-responsive materials where an external stimulus induces controlled variations in topography or mechanics. Herein, we describe the development of a dynamic cell culture substrate where mechanical properties are reversibly tuned in situ using magnetically-responsive superparamagnetic iron oxide nanoparticles (SPIONs).

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Published

2019-02-27

How to Cite

[1]
F. Crippa, B. Rothen-Rutishauser, A. Petri-Fink, Chimia 2019, 73, 51, DOI: 10.2533/chimia.2019.51.