A Personal Account on Industrial Collaborations in the Field of C–H Activation
Keywords:bioactive molecules, C-H activation, catalysis, palladium
AbstractIn recent years, transition-metal-catalyzed C–H functionalization has emerged as a potentially greener alternative to classic cross-couplings and as a powerful tool to access complex functional molecules with improved step-economy. This short account relates our experience of industrial collaborations in C(sp3)–H bond activation, which were key to the development of this topic in our group. The synthesis of the antianginal drug Ivabradine led us to develop a general approach to benzocyclobutenes, which were further employed in pericyclic reactions. A follow-up study led us to discover a new method to construct arylcyclopropanes via double C–H activation and the coupling of two alkyl groups. Finally, targeting the herbicide Indaziflam contributed to develop C(sp3)–H activation as a powerful tool to access a variety of relevant indane motifs. We hope that these successful stories will help to stimulate further fruitful Industry-Academia collaborations in the field of synthetic chemistry.
How to Cite
O. Baudoin, Chimia 2021, 75, 967, DOI: 10.2533/chimia.2021.967.
Copyright (c) 2021 Olivier Baudoin
This work is licensed under a Creative Commons Attribution 4.0 International License.