Very Lipophilic Ca2⊕-Selective Ionophore for Chemical Sensors of High Lifetime

Abstract

Ionophores based on 3-oxapentane-1,5-diamide derivatives with water/1-n-octanol partition coefficients up to 10²² were synthesized. They have sufficient lipophilicity to be used in solvent polymeric membranes for optodes, ISFET’s, and ion-selective electrodes with a lifetime from 600 to 4∙10⁶ hours even in permanent contact with whole blood or undiluted blood serum. Selectivities of Ca^2⊕ over Mg^2⊕, Na^⊕ and K^⊕ of 10^4.2,10⁶ and 10⁸, respectively, were obtained.