Studies toward New Anti-Cancer Strategies Based on α-Mannosidase Inhibition
Keywords:Anti-cancer agents, Endothelial cells, Glioblastoma, α-mannosidase inhibitors
Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression. Following the studies on swainsonine, a natural inhibitor of Golgi α-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of α-mannosidases II able to induce antiproliferative effects in human cancer cells.
How to Cite
Copyright (c) 2010 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.