Studies toward New Anti-Cancer Strategies Based on α-Mannosidase Inhibition

Sandrine Gerber-Lemaire; Lucienne Juillerat-Jeanneret

doi:10.2533/chimia.2010.634

Studies toward New Anti-Cancer Strategies Based on α-Mannosidase Inhibition

Authors

Sandrine Gerber-Lemaire Werner Prize Winner 2010, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Batochime, CH-1015 Lausanne, Switzerland;, Email: Sandrine.Gerber@epfl.ch
Lucienne Juillerat-Jeanneret University Institute of Pathology, CHUV, CH-1011 Lausanne

DOI:

https://doi.org/10.2533/chimia.2010.634

Keywords:

Anti-cancer agents, Endothelial cells, Glioblastoma, α-mannosidase inhibitors

Abstract

Changes in the glycosylation pattern of cellular glycoproteins constitute a hallmark in human cancer and influence tumor progression, suggesting that inhibitors of selected glycosidases may control cancer progression. Following the studies on swainsonine, a natural inhibitor of Golgi α-mannosidase II, which highlighted the inhibition of cellular mannosidases as a potential innovative approach for the treatment of cancer, several dihydroxylated pyrrolidines and analogues were developed as new potent inhibitors of α-mannosidases II able to induce antiproliferative effects in human cancer cells.