Bioinspired Hydrogels for 3D Organoid Culture

Authors

  • Delphine Blondel
  • Matthias P. Lutolf

DOI:

https://doi.org/10.2533/chimia.2019.81

PMID:

30814005

Keywords:

Ecm, Hydrogel, Matrigeltm, Organoid, Photo-patterning, Synthetic gel, Self-healing

Abstract

Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.

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Published

2019-02-27

How to Cite

[1]
D. Blondel, M. P. Lutolf, Chimia 2019, 73, 81, DOI: 10.2533/chimia.2019.81.