Recent Advances in Mode of Action and Biosynthesis Studies of the Clinically Used Antibiotic Fidaxomicin

Authors

  • Andrea Dorst University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
  • Erik Jung University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
  • Karl Gademann University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland;, Email: karl.gademann@chem.uzh.ch

DOI:

https://doi.org/10.2533/chimia.2020.270

Keywords:

Antibiotics, Biosynthesis, Mode of action, Natural products, Sar studies

Abstract

The natural product antibiotic fidaxomicin is a marketed drug for the treatment of bacterial infections in the gut. Due to its promising in vitro activities against Mycobacterium tuberculosis, the development of next generation fidaxomicin analogs is of great interest. This article reviews the most recent advances, including the elucidation of a unique mode of action by cryo-EM structures, and the efforts towards the clarification of the biosynthetic pathway. Moreover, known fidaxomicin analogs and their reported antibacterial activities are summarized.

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Published

2020-04-29

How to Cite

[1]
A. Dorst, E. Jung, K. Gademann, Chimia 2020, 74, 270, DOI: 10.2533/chimia.2020.270.