Impact of DNA-Encoded Chemical Library Technology on Drug Discovery

Michelle Keller; Kristina Schira; Jörg Scheuermann

doi:10.2533/chimia.2022.388

Impact of DNA-Encoded Chemical Library Technology on Drug Discovery

Authors

Michelle Keller Dept. of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, 8093 Zürich https://orcid.org/0000-0002-3996-4240
Kristina Schira Dept. of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, 8093 Zürich https://orcid.org/0000-0002-6548-331X
Jörg Scheuermann Dept. of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zürich, 8093 Zürich https://orcid.org/0000-0001-7746-4717

DOI:

https://doi.org/10.2533/chimia.2022.388

Keywords:

DNA-Encoded Chemical Library, small-molecule drug discovery, affinity-based screening

Abstract

DNA-Encoded Chemical Libraries (DELs) have gained momentum over the recent years for the discovery of small-molecule ligands and the technology has been integrated in most of the larger pharmaceutical companies. With this perspective we would like to summarize the development of DEL technology and present some representative DEL-derived hits which may soon enter the pharmaceutical market.