Vol. 76 No. 5 (2022): Medicinal Chemistry

Editorial

• Editorial

  Karl-Heinz Altmann

  385

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Scientific Articles

• Impact of DNA-Encoded Chemical Library Technology on Drug Discovery

  Michelle Keller, Kristina Schira, Jörg Scheuermann

  388

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• Generating Bioactive Natural Product-inspired Molecules with Machine Intelligence

  Petra Schneider, Karl-Heinz Altmann, Gisbert Schneider

  396

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• Targeting Extracellular Bacterial Proteases for the Development of Novel Antivirulence Agents

  Cansu Kaya, Anna K. H. Hirsch

  402

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• Comparison of the Old and New - Novel Mechanisms of Action for Anti-coronavirus Nucleoside Analogues

  Joy E. Thames, Katherine L. Seley-Radtke

  409

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• The Bitter Taste Receptor TAS2R14 as a Drug Target

  Lukas A. W. Waterloo, Stefan Löber, Peter Gmeiner

  418

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• Reverse Design toward Optimized Labeled Chemical Probes – Examples from the Endocannabinoid System

  Mónica Guberman, Miroslav Kosar, Anahid Omran, Erick M. Carreira, Marc Nazaré, Uwe Grether

  425

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• Never Gonna Give You Up – Current Developments in Covalent Protein Kinase Inhibitors

  Laura Hillebrand, Matthias Gehringer

  435

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• Current HDAC Inhibitors in Clinical Trials

  Elisabetta Di Bello, Beatrice Noce, Rossella Fioravanti, Antonello Mai

  448

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• The Role of Transporters in Future Chemotherapy

  Johanna Huttunen, Kristiina M. Huttunen

  454

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• Protein Phosphatases: A Neglected Target Family for Drug Discovery

  Joe Lewis, Gerhard Müller

  460

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• Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future

  Jonathan Hall, Anastasia Ashkinadze, Jan Philipp Becker, Artur Laski, Eva-Maria Manz, Štefan Moravčík, Sebastian Sjöström, Mathilde Vincent

  466

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Columns, Conference Reports

• Swiss Science Concentrates

  Valentina Marchini, Lauriane Pillet, Lucia Robustini, Stefania Gianolio, Francesca Paradisi

  474

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• Robinia pseudoacacia (Black Locust) – An Invasive Species with Unsuspected Potential in Grappa Ageing Highlights of Analytical Sciences in Switzerland

  Pascal Fuchsmann, Mireille Tena Stern, Sonia Petignat-Keller, Jonas Inderbitzin, Mark Bertogliati, Marilyn Cléroux, Benoit Bach

  476

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• Near-Quantitative, Catalyst-Free Depolymerization of RAFT Polymethacrylates Polymer and Colloid Highlights

  Hyun Suk Wang, Nghia P. Truong, Athina Anastasaki

  477

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• Elastin-like Polypeptides: Protein-based Polymers for Biopharmaceutical Development Medicinal Chemistry and Chemical Biology Highlights

  Michael A. Nash

  478

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• Review of Recent Literature on Flow Chemistry. Selected Topic: Electrochemistry Flow Chemistry Highlights

  Agnieszka Ladosz, Benjamin Martin

  480

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• Teaching Acid-Base Equilibria by Using Log-log Diagrams Chemical Education

  Antonio Togni

  481

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• Blue LED Mediated C-H and N-H Insertion of Indoles into Aryldiazoesters and Iodonium Ylides FH-HES Universities of Applied Sciences

  Ludovic Gremaud, Subhabrata Sen

  483

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• DMCCB Basel Symposium 2022: Intrinsically Disordered Proteins as Drug Targets, Online, 31st January, 2022 Conference Report

  Elyse T. Williams, Nina Hartrampf

  493

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Community News

• Community News

  496

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Events

• Congresses, Symposia, Lectures, Education Courses

  508

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• Impressum

  516

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