Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future

Jonathan Hall; Anastasia Ashkinadze; Jan Philipp Becker; Artur Laski; Eva-Maria Manz; Štefan Moravčík; Sebastian Sjöström; Mathilde Vincent

doi:10.2533/chimia.2022.466

Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future

Authors

Jonathan Hall Dept. Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich https://orcid.org/0000-0003-4160-7135
Anastasia Ashkinadze Dept. Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich https://orcid.org/0000-0003-1528-4176
Jan Philipp Becker Dept. Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich https://orcid.org/0000-0002-8521-626X
Artur Laski Dept. Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich https://orcid.org/0000-0001-6552-5367
Eva-Maria Manz Dept. Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich https://orcid.org/0000-0002-6085-6914
Štefan Moravčík Dept. Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich https://orcid.org/0000-0001-5823-7826
Sebastian Sjöström Dept. Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich https://orcid.org/0000-0002-7726-099X
Mathilde Vincent Dept. Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich https://orcid.org/0000-0001-7189-8354

DOI:

https://doi.org/10.2533/chimia.2022.466

Keywords:

Antisense, Gapmer, Oligonucleotide, Small interfering RNA

Abstract

The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years. Much of the progress in this field is due to advances in the medicinal chemistry of oligonucleotides,combined with a judicious choice of molecular targets and disease areas. In this perspective, we describe the growth of this new class of drugs highlighting selected milestones in oligonucleotide medicinal chemistry.

CHIMIA Vol. 76 No. 5 (2022): Medicinal Chemistry

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Published

2022-05-25

How to Cite

[1]

J. Hall, A. Ashkinadze, J. P. Becker, A. Laski, E.-M. Manz, Štefan Moravčík, S. Sjöström, M. Vincent, Chimia 2022, 76, 466, DOI: 10.2533/chimia.2022.466.