Generation and Use of Reactive Intermediates Exploiting Flow Technology

Abstract

Continuous flow technology has matured into a valuable and widely exploited technology across academic and industrial laboratories. The safe and on-demand generation of reactive intermediates using miniaturized flow set-ups is of particular value to realize safer and more streamlined synthesis routes yielding important chemical building blocks. This focused review provides an update on recent studies highlighting the use of photochemistry, metalation reactions and electrochemistry to generate a variety of reactive intermediates showcasing successful implementations of flow processing as well as areas offering further opportunities.