Application of High Resolution Mass Spectrometry in Organic Chemistry

Abstract

High resolution techniques combined with accurate mass measurement enable more precise information to be obtained on the atomic composition of ions in the mass spectrum of an organic compound than has previously been possible with the more usual single focusing mass spectrometers.
A description of these high resolution techniques and of a method for the rapid and precise measurement of mass is given and their application to the examination of organic compounds illustrated with examples. A brief description is also given of a double focusing mass spectrometer that has been specifically designed for this work and which incorporates these techniques; the instrument has a resolving power in excess of 10,000 and an accuracy of mass measurement better than 1 part in 10⁵.