Dünnschichtchromatographische Untersuchung von Imipramin

Authors

  • K. Adank Wissenschaftliche Laboratorien der J. R. Geigy AG, Basel
  • W. Hammerschmidt Wissenschaftliche Laboratorien der J. R. Geigy AG, Basel

DOI:

https://doi.org/10.2533/chimia.1964.361

Abstract

Thin layer chromatography applied to commercial imipramine (Tofranil®) demonstrates the presence of less than 0.2% impurity. These impurities consist of eight compounds. The concentration of no single entity exceeds 0.05%. Highly fluorescent N-substituted acridines are present in amounts of less than 0.1%. On the basis of pharmacologic studies, these impurities could not lead to unfavorable side effects at the level in which they are present in commercial Tofranil®.

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Published

1964-11-30

Issue

Vol. 18 No. 11 (1964): Forschung/Research

Section

Kurze Mitteilungen

License

Copyright (c) 1964 K. Adank

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
K. Adank, W. Hammerschmidt, Chimia 1964, 18, 361, DOI: 10.2533/chimia.1964.361.