Structural Modification of the Immunosuppressants FK-506 and Ascomycin Using a Biological Approach
AbstractBioconversion was utilized to conduct structural modification of the complex molecules FK-506 and ascomycin. Four interesting microbial reactions, regiospecific O-demethylation, glucosylation, hydroxylation, and phosphorylation, yielding various derivatives of the title compounds, were discovered from screening more than thousand microorganisms including bacteria, actinomycetes, and fungi. The isolated compounds were evaluated for a better understanding of structural and functional features responsible for their biological activity.
How to Cite
T. S. Chen, X. Li, B. Petuch, A. Shafiee, L. So, Chimia 1999, 53, 596, DOI: 10.2533/chimia.1999.596.
Copyright (c) 1999 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.