Structural Modification of the Immunosuppressants FK-506 and Ascomycin Using a Biological Approach

Authors

  • Tom S. Chen
  • Xiaohua Li
  • Brian Petuch
  • Ali Shafiee
  • Lydia So

DOI:

https://doi.org/10.2533/chimia.1999.596

Abstract

Bioconversion was utilized to conduct structural modification of the complex molecules FK-506 and ascomycin. Four interesting microbial reactions, regiospecific O-demethylation, glucosylation, hydroxylation, and phosphorylation, yielding various derivatives of the title compounds, were discovered from screening more than thousand microorganisms including bacteria, actinomycetes, and fungi. The isolated compounds were evaluated for a better understanding of structural and functional features responsible for their biological activity.

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Published

1999-12-22

Issue

Section

Scientific Articles

How to Cite

[1]
T. S. Chen, X. Li, B. Petuch, A. Shafiee, L. So, Chimia 1999, 53, 596, DOI: 10.2533/chimia.1999.596.