Tuning Molecular Recognition of RNA and DNA via Sugar Modification

Authors

  • Christian J. Leumann

DOI:

https://doi.org/10.2533/000942905777675624

Keywords:

Antisense, Dna recognition, Dna triple-helix, Molecular beacons, Pyrrolidino nucleosides

Abstract

This minireview highlights three aspects of our recent work in the area of sugar modified oligonucleotide analogues. It provides an overview over recent results on the conformationally constrained analogue tricyclo-DNA with special emphasis of its antisense properties, it summarizes results on triple-helix forming oligodeoxynucleotides containing pyrrolidino-nucleosides with respect to DNA recognition via the dual recognition mode, and it highlights the advantageous application of the orthogonal oligonucleotidic pairing system homo-DNA in molecular beacons for DNA diagnostics.

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Published

2005-11-01

Issue

Section

Scientific Articles