Searching for Nucleic Acid Alternatives

Authors

  • Albert Eschenmoser

DOI:

https://doi.org/10.2533/000942905777675552

Keywords:

Conformational analysis of oligonucleotides, Nucleic acid analogs, Oligonucleodipeptides, P-rna, Tna, Watson-crick base-pairing

Abstract

"Back of the envelope" methods have their place in experimental chemical research; they are effective mediators in the generation of research ideas, for instance, the design of molecular structures. Their qualitative character is part of their strength, rather than a drawback for the role they have to play. Qualitative conformational analysis of oligonucleotide and other oligomer systems on the level of idealized conformations is one such method; it has played a helpful role in our work on the chemical etiology of nucleic acid structure. This article, while giving a short overview of that work, shows how.

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Published

2005-11-01

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Section

Scientific Articles