Optical Detection of Very Small Nonfluorescent Nanoparticles
Keywords:Interferometric detection, Label-free, Nanoparticle, Optical microscopy, Particle tracking
AbstractWe discuss an interferometric method for the optical detection of very small nonfluorescent nanoparticles. In particular, we show that single gold nanoparticles with a diameter as small as 5 nm can be detected. We discuss the potential of such tiny particles as optical labels for biological studies. Furthermore, we show that our interferometric method can be also used for the detection and tracking of unlabelled biological nano-entities such as viruses or microtubuli.
How to Cite
V. Sandoghdar, E. Klotzsch, V. Jacobsen, A. Renn, U. Håkanson, M. Agio, I. Gerhardt, J. Seelig, G. Wrigge, Chimia 2006, 60, 761, DOI: 10.2533/chimia.2006.761.
Copyright (c) 2006 Swiss Chemical Society
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