Thermal Cleavage of the Fmoc Protection Group
FH – HES
Keywords:Dibenzofulvene, Fmoc protection group, High-temperature nmr, Peptide synthesis, Thermal cleavage
AbstractThe Fmoc protection group is among the most commonly used protection groups for the amino function. A fast method for the thermal deavage of this protection group under base-free conditions without the need for dibenzofulvene scavengers is presented. The advantages of this method include straightforward testability by means of a simple high-temperature NMR experiment, usually high yields, and good selectivity towards the BOC protection group and t-butyl ethers.
How to Cite
S. Höck, R. Marti, R. Riedl, M. Simeunovic, Chimia 2010, 64, 200, DOI: 10.2533/chimia.2010.200.
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