Syntheses and Biological Activities of 1,4-Iminoalditol Derivatives as ?-L-Fucosidase Inhibitors

Elena Moreno-Clavijo; Ana T. Carmona; Antonio J. Moreno-Vargas; Lidia Molina; Inmaculada Robina

doi:10.2533/chimia.2011.40

Syntheses and Biological Activities of 1,4-Iminoalditol Derivatives as ?-L-Fucosidase Inhibitors

Authors

Elena Moreno-Clavijo Dept. Organic Chemistry Faculty of Chemistry University of Seville P. O. Box 1203, E-41071 Seville, Spain
Ana T. Carmona Dept. Organic Chemistry Faculty of Chemistry University of Seville P. O. Box 1203, E-41071 Seville, Spain;, Email: anatere@us.es
Antonio J. Moreno-Vargas Dept. Organic Chemistry Faculty of Chemistry University of Seville P. O. Box 1203, E-41071 Seville, Spain
Lidia Molina Dept. Organic Chemistry Faculty of Chemistry University of Seville P. O. Box 1203, E-41071 Seville, Spain
Inmaculada Robina Dept. Organic Chemistry Faculty of Chemistry University of Seville P. O. Box 1203, E-41071 Seville, Spain;, Email: robina@us.es

DOI:

https://doi.org/10.2533/chimia.2011.40

Keywords:

Fucosidases, Glycosidase inhibitors, Iminosugars, Pyrrolidines

Abstract

A review dealing with 1,4-iminoalditol (hydroxylated pyrrolidine) derivatives as inhibitors of ?-L-fucosidases including the different synthetic approaches for their preparation as well as their inhibitory properties is presented.