NMR Spectroscopy: An Excellent Tool to Understand RNA and Carbohydrate Recognition by Proteins
Keywords:Nmr spectroscopy, Protein–carbohydrate complex, Protein–rna complex, Protein structure, Specific interaction
AbstractStructural biology plays a key role in understanding how networks of protein interactions with their partners are organized at the atomic level. In this review, we show that NMR is a very efficient method to solve 3D structures of protein – RNA and protein–carbohydrate complexes of high quality. We explain the importance of studying such interactions and describe the main steps that are required to determine structures of these types of complexes by NMR. Finally, we show that X-ray crystallography and NMR are complementary methods and briefly report on advantages and disadvantages of each approach.
How to Cite
A. Cléry, M. Schubert, F. H.-T. Allain, Chimia 2012, 66, 741, DOI: 10.2533/chimia.2012.741.
Copyright (c) 2012 Swiss Chemical Society
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