Quantification and Analysis of Intramolecular Interactions
Keywords:Chemical hamiltonian approach (cha), Interacting quantum atoms (iqa), Intramolecular interactions, Natural bond orbital (nbo), Strictly localized orbitals (slos), Symmetry-adapted perturbation theory (sapt)
AbstractNon-covalent interactions play a prominent role in chemistry and biology. While a myriad of theoretical methods have been devised to quantify and analyze intermolecular interactions, the theoretical toolbox for the intramolecular analogues is much scarcer. Yet interactions within molecules govern fundamental phenomena as illustrated by the energetic differences between structural isomers. Their accurate quantification is of utmost importance. This paper gives an overview of the most common approaches able to probe intramolecular interactions and stresses both their characteristics and limitations. We finally introduce our recent theoretical approach, which represents the first step towards the development of an intramolecular version of Symmetry-Adapted Perturbation Theory (SAPT).
How to Cite
J. F. Gonthier, C. Corminboeuf, Chimia 2014, 68, 221, DOI: 10.2533/chimia.2014.221.
Copyright (c) 2014 Swiss Chemical Society
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