Inflammasomes in Host Defense and Autoimmunity

Authors

  • Petr Broz Biozentrum University of Basel, Klingelbergstrasse 50-70, CH-4056 Basel, Switzerland. petr.broz@unibas.ch

DOI:

https://doi.org/10.2533/chimia.2016.853

Keywords:

Autoimmunity, Infectious diseases, Inflammasomes, Inflammation, Innate immunity

Abstract

Inflammasomes are large multi-protein complexes that control host defense and inflammation during infections with pathogens. Their clinical importance however reaches beyond infectious disease, since dysregulated inflammasome activity has also been linked to many auto-inflammatory disorders. This article gives a short overview on the basics of inflammasome signaling, their activation mechanisms and their role in autoimmunity.

Downloads

Published

2016-12-21

How to Cite

[1]
P. Broz, Chimia 2016, 70, 853, DOI: 10.2533/chimia.2016.853.