Recent Development of Photo-Cross-Linkers as Tools for Biomedical Research
Keywords:Genetic encoding, Photo-affinity probe, Photo-cross-linker, Protein–protein interaction, Target identification
AbstractPhoto-cross-linkers are invaluable tools for identifying drug targets and off-targets as well as probing the binding sites in medicinal chemistry and chemical biology. In this review, we summarize recent development of the ligand-based and genetically encoded photo-cross-linkers and their use in biological system. In particular, we highlight our discovery of 2-aryl-5-carboxytetrazole (ACT) as a novel class of photo-cross-linkers and their successful applications in drug target identification as well as identifying transient protein–protein interaction complexes in mammalian cells.
How to Cite
Y. Tian, Q. Lin, Chimia 2018, 72, 758, DOI: 10.2533/chimia.2018.758.
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