Bioinspired Non-Heme Iron Complexes: The Evolution of Facial N, N, O Ligand Design
Keywords:Bioinspired metal complexes, 2-his-1-carboxylate facial triad, N,n,o ligands, Non-heme iron
AbstractIron-containing metalloenzymes that contain the 2-His-1-Carboxylate facial triad at their active site are well known for their ability to activate molecular oxygen and catalyse a broad range of oxidative transformations. Many of these reactions are synthetically challenging, and developing small molecular iron-based catalysts that can achieve similar reactivity and selectivity remains a long-standing goal in homogeneous catalysis. This review focuses on the development of bioinspired facial N,N,O ligands that model the 2-His-1-Carboxylate facial triad to a greater degree of structural accuracy than many of the polydentate N-donor ligands commonly used in this field. By developing robust, well-defined N,N,O facial ligands, an increased understanding could be gained of the factors governing enzymatic reactivity and selectivity.
How to Cite
E. C. Monkcom, P. Ghosh, E. Folkertsma, H. A. Negenman, M. Lutz, R. J. M. Klein Gebbink, Chimia 2020, 74, 450, DOI: 10.2533/chimia.2020.450.
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