Aiming for More Sustainable Cross-Coupling Chemistry by Employing Single-Atom Catalysis on Scale

Authors

  • Dario Poier Institute of Chemical Technology, Haute école d’Ingénierie et d’Architecture Fribourg, HES-SO University of Applied Sciences and Arts Western Switzerland, Boulevard de Pérolles 80, CH-1700 Fribourg; Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 Zurich https://orcid.org/0000-0003-0587-7007
  • Sharon Mitchell Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 Zurich https://orcid.org/0000-0002-3933-2913
  • Victor Tulus Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 Zurich https://orcid.org/0000-0001-8774-9492
  • Gonzalo Guillén-Gosálbez Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 Zurich https://orcid.org/0000-0001-6074-8473
  • Javier Pérez-Ramírez Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir- Prelog-Weg 1, CH-8093 Zurich https://orcid.org/0000-0002-5805-7355
  • Roger Marti Institute of Chemical Technology, Haute école d’Ingénierie et d’Architecture Fribourg, HES-SO University of Applied Sciences and Arts Western Switzerland, Boulevard de Pérolles 80, CH-1700 Fribourg https://orcid.org/0000-0001-6308-4908

DOI:

https://doi.org/10.2533/chimia.2023.127

PMID:

38047815

Keywords:

Cross-Coupling Reactions, Life-cycle assessment, Process Chemistry, Single-Atom Catalysis, Sustainability

Abstract

Scaling up syntheses from mg to kg quantities is a complex endeavor. Besides adapting laboratory protocols to industrial processes and equipment and thorough safety assessments, much attention is paid to the reduction of the process’ environmental impact. For processes including transition metal catalyzed steps, e.g. cross-coupling chemistry, this impact strongly depends on the identity of the metal used. As such, a key approach is the replacement of single-use with reusable heterogeneous catalysts. Transition metal single-atom heterogeneous catalysts (SAC), a novel class of catalytic materials, might exhibit all the necessary properties to step up to this task. This article shall discuss current applications of SAC in cross-coupling chemistry from the point of a process chemist and shed light on the NCCR Catalysis contribution to the field. Investigations of the stability-activity-selectivity relationship of SACs in combination with early-stage life-cycle assessments (LCA) of potential processes lay the foundation for large-scale application tailored catalyst synthesis. Ultimately, prevailing challenges are highlighted, which need to be addressed in future research.

Funding data

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Published

2023-03-29

Issue

Section

Scientific Articles

How to Cite

[1]
D. Poier, S. Mitchell, V. Tulus, G. Guillén-Gosálbez, J. Pérez-Ramírez, R. Marti, Chimia 2023, 77, 127, DOI: 10.2533/chimia.2023.127.