Leveraging Radical Ligand Transfer Catalysis for the Construction of Carbon-Heteroatom Bonds

Abstract

Radical ligand transfer (RLT) has emerged as a powerful strategy for the selective construction of carbon–heteroatom bonds through the interception of carbon-centred radicals by redox-active metal complexes. This review highlights recent contributions from our group to RLT-mediated catalysis synergized with electrochemical, photochemical, and mechanochemical activation modes. These RLT-based strategies enabled the development of electrochemical halonitration reactions, photoredox nitrative difunctionalization, and carbochlorination of alkenes, and more recently, mechanochemical nitronitrooxylation, and vicinal dehalogenation reactions. Together, these studies establish RLT as a versatile and sustainable platform for radical-mediated carbon–heteroatom bond formation.