Preparation of Chiral 2,4-Dimethylglutaric Acid Monoesters from the Racemic Diesters by means of Microbes and Microbial Esterases

Authors

  • Gerardo M. Ramos Tombo Central Research Laboratories and Biotechnology Department of Ciba-Geigy AG,K-121.2.11 Postfach, CH-4002 Basel
  • Hans-Peter Schär Central Research Laboratories and Biotechnology Department of Ciba-Geigy AG,K-121.2.11 Postfach, CH-4002 Basel
  • Willy Zimmermann Central Research Laboratories and Biotechnology Department of Ciba-Geigy AG,K-121.2.11 Postfach, CH-4002 Basel
  • Oreste Ghisalba Central Research Laboratories and Biotechnology Department of Ciba-Geigy AG,K-121.2.11 Postfach, CH-4002 Basel

DOI:

https://doi.org/10.2533/chimia.1985.313

Abstract

After an extensive screening, some specialized methylotrophs as well as a Streptomyces strain were found to be useful sources of esterases catalyzing the enantioselective hydrolysis of racemic 2,4-dimethylglutaric acid dimethyl ester (3) and diethyl ester (4) to the corresponding optically active monoesters 5 or 9 and 7 or 11, respectively.

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Published

1985-10-31

Issue

Vol. 39 No. 10 (1985): Forschung/Research

Section

Articles

License

Copyright (c) 1985 Gerardo M. Ramos Tombo

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
G. M. Ramos Tombo, H.-P. Schär, W. Zimmermann, O. Ghisalba, Chimia 1985, 39, 313, DOI: 10.2533/chimia.1985.313.