Chemo-Enzymatic Synthesis of Chiral Fluorine-Containing Building Blocks
Keywords:Asymmetric hydrogenation, Chiral building blocks, Enzymatic resolution, Fluorinated amino acids, Transition metal catalysis
AbstractTwo complementary strategies for the synthesis of optically active fluorine-containing building blocks have been probed. The first strategy involves either the enzymatic resolution of fluorinated ?,?-disubstituted-?-amino acid amides, or the asymmetric hydrogenation of fluorinated dehydroamino acids. The second strategy involves the transition metal-catalyzed introduction of fluorine-containing substituents onto olefin- or acetylene-containing ?-H-?-amino acids. These amino acids in turn are made optically active by enzymatic resolution of the corresponding amides.
How to Cite
R. H. Blaauw, D. R. Ijzendoorn, J. G. Cremers, F. P. Rutjes, Q. B. Broxterman, H. E. Schoemaker, Chimia 2004, 58, 104, DOI: 10.2533/000942904777678127.
Copyright (c) 2004 Swiss Chemical Society
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