Encoded Self-Assembling Chemical Libraries

Authors

  • Samu Melkko
  • Jens Sobek
  • Greta Guarda
  • Jörg Scheuermann
  • Christoph E. Dumelin
  • Dario Neri

DOI:

https://doi.org/10.2533/000942905777675525

Keywords:

Affinity maturation, Combinatorial chemistry, Dna-templated chemistry, Encoded self-assembling chemical libraries, Lead identification

Abstract

The display of chemical moieties at the extremity of synthetic oligonucleotides allows the self-assembly of large chemical libraries in which every chemical moiety is associated to a unique DNA sequence, serving as an 'identification bar code'. In this article, we describe the principles, the potential, and the challenges of this novel technology, which promises to facilitate the isolation of high-affinity binders to protein targets of biological and pharmaceutical interest.

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Published

2005-11-01

How to Cite

[1]
S. Melkko, J. Sobek, G. Guarda, J. Scheuermann, C. E. Dumelin, D. Neri, Chimia 2005, 59, 798, DOI: 10.2533/000942905777675525.

Issue

Vol. 59 No. 11 (2005): Modified Oligonucleotides

Section

Scientific Articles

License

Copyright (c) 2005 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.