Bimorpholines as Alternative Organocatalysts in Asymmetric Aldol Reactions

Authors

  • Kadri Kriis
  • Marju Laars
  • Kristin Lippur
  • Tõnis Kanger

DOI:

https://doi.org/10.2533/chimia.2007.232

Keywords:

Aldol condensation, Bimorpholine, Organocatalysis, Stereoselective

Abstract

Asymmetric organocatalytic aldol condensation is discussed on the basis of intramolecular and inter-molecular reactions. In addition to the widely used proline and its derivatives an application of the new type of the organocatalyst – bimorpholines in the above-mentioned reactions is described. The new catalyst has a unique C2-symmetric skeleton with four acceptor sites that makes it stereoselective and efficient. Small changes in the structure of the catalyst lead to a remarkable loss of selectivity.

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Published

2007-05-30

Issue

Section

Scientific Articles

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