Active Methylene-based Multicomponent Reactions under Microwave Heating

Authors

  • Bo Jiang Suzhou University, China
  • Shu-Jiang Tu Xuzhou Normal University, P. R. China College of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, China. jiangchem@xznu.edu.cn

DOI:

https://doi.org/10.2533/chimia.2011.925

Keywords:

Active methylene compounds, Green synthesis, Heterocycles, Microwave heating, Multicomponent reaction

Abstract

The use of emerging multicomponent reactions (MCRs) in conjunction with microwave (MW)-assisted chemistry techniques is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. MW-assisted active methylene-based multicomponent reactions serve as a rapid and efficient tool for the synthesis of versatile heterocycles, particularly those containing structural diversity and complexity via a one-pot operation. This minireview covers our recent advances on multicomponent reactions involving active methylene compounds for the construction of bioactive molecule skeletons. In many cases, MW-assisted MCRs offer considerable improvements in selectivity, chemical yield and purity and constitutes a very simple and extremely rapid method to access a diverse range of heterocyclic motifs.

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Published

2011-12-14

How to Cite

[1]
B. Jiang, S.-J. Tu, Chimia 2011, 65, 925, DOI: 10.2533/chimia.2011.925.

Issue

Section

Scientific Articles