Heteroatom Nucleophile Induced C–C Fragmentations to Access Functionalized Allenes
Keywords:Allenes, Cyclization, Domino reactions, Fragmentation, Radicals
AbstractThe rich structural and reactivity profile of allenes render them versatile synthetic intermediates. However, application of allenes in organic chemistry is often attenuated by inconvenient methods of preparation. Herein we present an operationally simple route to functionalized allenes from vinyl triflate precursors through a Grob-type fragmentation induced by heteroatom nucleophiles such as water, alcohols, thiols or amines. The fragmentation occurs under mild conditions and is well suited for one-pot or domino processes allowing access to a range of synthetically useful intermediates.
How to Cite
T. Saget, N. Cramer, Chimia 2012, 66, 205, DOI: 10.2533/chimia.2012.205.
Copyright (c) 2012 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.