Ruthenium-based Photocatalysis in Templated Reactions

Authors

  • Jacques Saarbach Faculty of Science, Department of Organic Chemistry NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland. jacques.saarbach@unige.ch
  • Eric Lindberg Faculty of Science, Department of Organic Chemistry NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland
  • Nicolas Winssinger Faculty of Science, Department of Organic Chemistry NCCR Chemical Biology, University of Geneva, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland. nicholas.winssinger@unige.ch

DOI:

https://doi.org/10.2533/chimia.2018.207

Keywords:

Fluorescent probes, Nucleic acid sensing, Protein imaging, Ruthenium photocatalysis, Templated chemistry

Abstract

Templated reactions proceed by bringing reagents in close proximity through their interaction with a template thus raising their effective concentrations. Templated reactions empower chemists to perform reactions at low concentrations in complex environments. Herein, we discuss our work on templated reactions leveraged on ruthenium photocatalysis. Over the past five years, we have used this reaction to uncage reporter molecules and sense or image nucleic acids or proteins of interest. The ruthenium photocatalysis chemistry has proven to be extremely robust and compatible with complex biological environments.

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Published

2018-04-25

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