Transforming Olefins into Dinucleophiles

Authors

  • Andrés García-Domínguez Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
  • Cristina Nevado Department of Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich. cristina.nevado@chem.uzh.ch

DOI:

https://doi.org/10.2533/chimia.2018.212

Keywords:

Cross-coupling, Dicarbofunctionalization, Nickel catalysis, Tdae

Abstract

Herein we present the first example of a three-component dicarbofunctionalization of olefins under reductive conditions. Our strategy takes advantage of nickel catalysis to add aryl and alkyl groups across the double bond with remarkable selectivity. The reaction shows broad functional group compatibility and more importantly, it proves to be general in terms of the alkenes that can be functionalized compared to previous dicarbofunctionalization methods. Initial control experiments reveal different activation modes for both electrophiles and the involvement of alkyl radicals throughout the reaction.

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Published

2018-04-25

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