New Directions in Transition Metal Catalyzed Carbonylation Chemistry
Keywords:Carbonylation, Catalysis, Fluorination, Isotope labeling, Nickel, Palladium
AbstractCarbon monoxide (CO) represents an important C1-building block for the construction of some of the most fundamental chemical functionalities carrying a carbon–oxygen double bond. Transition metal catalysis plays a key role in promoting such transformations. We have earlier shown that the combination of palladium catalysis with CO releasing molecules and the two-chamber reactor, COware, provides a convenient and safe means for performing traditional Pd-catalyzed carbonylative couplings, as well as being a platform for the discovery of new carbonylation reactions. Furthermore, the method can be adapted to 13C- and 14C-isotope labeling, as well as providing for a suitable setting for developing efficient carbonylation reactions with 11CO. Herein, we provide a short overview of our latest findings in this area with emphasis on carbonylative couplings with fluorinated building blocks, but also discuss our efforts to develop viable Ni-catalyzed carbonylations with aliphatic substrates, which can be performed efficiently under low CO partial pressures.
How to Cite
D. U. Nielsen, K. T. Neumann, T. Skrydstrup, Chimia 2018, 72, 606, DOI: 10.2533/chimia.2018.606.
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