The Xanthate Route to Amino Acids
Keywords:Amino acids, β-lactams, Native chemical ligation, Radical addition, Xanthates
AbstractThe degenerative xanthate addition transfer to alkenes allows the synthesis of a broad range of protected, and in some cases enantiopure, ?, ?, and ?-amino acids, including proline and pipecolic derivatives, as well as fluorinated congeners and ?-lactams. The radical addition furnishes naturally latent mercapto-?-amino acids that are ideally equipped for native chemical ligation. Most of the amino acid structures accessible rapidly by this chemistry would otherwise require tedious multi-step syntheses.
How to Cite
S. Z. Zard, Chimia 2020, 74, 9, DOI: 10.2533/chimia.2020.9.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.