Recent Developments and Aspects of Industrial Fluoroalkylation

Authors

  • Matthias Beller Leibnitz-Institut für Katalyse an der Universität Rostock e.V., Albert Einstein-Strasse 29a, 18059 Rostock
  • Florian Fischer Leibnitz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059 Rostock
  • Andreas Locher Arxada AG, Lonzastrasse, CH-3930 Visp
  • Helfried Neumann Leibnitz-Institut für Katalyse and der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059 Rostock
  • Christoph Taeschler Arxada AG, Lonzastrasse, CH-3930 Visp
  • Fei Ye Leibnitz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Strasse 29a, 18059 Rostock
  • Shaoke Zhang Leibnitz-Institut für Katalyse an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock

DOI:

https://doi.org/10.2533/chimia.2021.923

PMID:

34798914

Keywords:

Catalysis, Dithionite, Fluoroalkylation, Industry, Sulfinatodehalogenation

Abstract

Fluoroalkylations have received increasing attention in the academic and industrial environment due to the particular properties of the active ingredients, strongly influenced by fluoroalkyl substituents. The inherent difficulties of introducing a fluoroalkyl substituent into advanced intermediates has triggered the development of an enormous number of specialized reagents, which, however, are often not suitable for large scale applications. In contrast to this reagent based fluoroalkylation approach, the direct activation of industrially readily available fluoroalkyl halides could be more suitable for a large-scale processes. In this way the dithionite initiated fluoroalkylation as well as newly developed catalytic activated fluoroalkylation protocols were considered for industrial large-scale applications.

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Published

2021-11-11

How to Cite

[1]
M. Beller, F. Fischer, A. Locher, H. Neumann, C. Taeschler, F. Ye, S. Zhang, Chimia 2021, 75, 923, DOI: 10.2533/chimia.2021.923.