4-Membered Ring Carbocations: A Positive Development in the Synthesis of 3,3-Disubstituted Oxetanes and Azetidines

Authors

DOI:

https://doi.org/10.2533/chimia.2023.192

PMID:

38047794

Keywords:

Azetidines, Bioisosteres, Carbocations, Chemical Space, Oxetanes

Abstract

4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant. Here, we describe the generation of oxetane- and azetidine- benzylic carbocations as a general strategy to access valuable 3,3-disubstituted derivatives.

Funding data

Downloads

Published

2023-04-26

How to Cite

[1]
J. J. Rojas, J. A. Bull, Chimia 2023, 77, 192, DOI: 10.2533/chimia.2023.192.